Highly aerated cultures boost gluconic acid production by the yeast-like fungus Aureobasidium pullulans
نویسندگان
چکیده
The ability of Aureobasidium pullulans NCYC 4012 to produce gluconic acid (GA) was firstly studied in flask batch cultures and it found that GA productivity not affected by initial glucose concentration, but highest substrate uptake rate observed at concentration 80 g L−1. effect oxygen mass transfer, varied changing agitation aeration rates or total air pressure, evaluated A. stirred tank bioreactors. Higher productivities were attained conditions high transfer proven the use increased pressure 4 bar is an effective means supply cultures. At cells induced antioxidant intracellular enzyme superoxide dismutase cope with oxidative stress due oxygenation conditions. On other hand, extracellular oxidase activity reduced highly oxygenated conditions, suggesting opposite effects on this secretion production.
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ژورنال
عنوان ژورنال: Biochemical Engineering Journal
سال: 2021
ISSN: ['1873-295X', '1369-703X']
DOI: https://doi.org/10.1016/j.bej.2021.108133